منابع مشابه
Aldosterone synthase inhibitors in cardiovascular and renal diseases.
Aldosterone is involved in various cardiovascular pathologies, including hypertension, heart failure, atherosclerosis and fibrosis. Mineralocorticoid receptor (MR)-dependent and -independent, genomic and non-genomic processes mediate its complex effects. Spironolactone and eplerenone, both MR antagonists, are the only commercially available compounds targeting directly the actions of aldosteron...
متن کاملAldosterone synthase inhibitors in hypertension: current status and future possibilities
The renin-angiotensin aldosterone system is a critical mechanism for controlling blood pressure, and exerts most of its physiological effects through the action of angiotensin II. In addition to increasing blood pressure by increasing vascular resistance, angiotensin II also stimulates aldosterone secretion from the adrenal gland. Aldosterone acts to cause an increase in sodium and water reabso...
متن کاملSpecific Aldosterone Synthase Inhibition
We have come to appreciate the many physiological and pathophysiological functions of adrenal steroid hormones in health and disease and the benefits and adverse effects of therapeutic manipulations. Glucocorticoids are an indispensable component in the treatment of inflammatory conditions. Blockade of the mineralocorticoid receptor (MR) with spironolactone is a long-established diuretic therap...
متن کاملSmoking and Aldosterone Synthase Polymorphism
Polymorphism To the Editor: Hautanen and colleagues1 claim that dyslipidemic middle-aged men from the Helsinki Heart Study with the aldosterone synthase (CYP11B2, –344T/C) CC genotype who smoked were '5 times more likely to suffer a nonfatal myocardial infarction than nonsmokers of the same genotype during a follow-up period of 8.5 years. I think that this finding is likely to be spurious and r...
متن کاملAldosterone synthase inhibition in humans.
Aldosterone synthase (CYP11B2) inhibition has emerged as a new option for the treatment of hypertension, heart failure and renal disorders, in addition to mineralocorticoid receptor (MR) blockade. The aim is to decrease aldosterone concentrations in both plasma and tissues, thereby decreasing MR-dependent and MR-independent effects in the cardiac, vascular and renal target organs. LCI699 was th...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2013
ISSN: 1948-5875,1948-5875
DOI: 10.1021/ml4000589